Taurine

Taurine is a semi-essential sulphur amino acid derived from methionine and cysteine metabolism and promotes neurological function - neurotransmitter/neuromodulator, neurotrophin, antioxidant, and osmolyte.

  • Taurine levels are increased following brain injury and glucocorticoid administration and demonstrates strong neuroprotection and regeneration following injury.

  • Neuroprotector effect of a new taurine derivative, 2-(1-phenylethyl)-aminoethanesulfonyl-2-propylamide hydrochloride has been studied in rats with model compression spinal cord trauma. The drug favored restoration of the motor function of posterior extremities in rats with the model spinal cord trauma and significantly decreased the lethality in test animals

  • The new taurine derivative normalized the energy metabolism, lipid peroxidation and antioxidant system in animals with spinal cord trauma

  • Taurine administration could prevent the onset of diabetes mellitus and/or insulin resistance type 1 and 2 diabetes mellitus

  • Taurine reverses neurological and neurovascular deficits in experimental type 2 diabetes

  • Liver and brain are the major organs responsible for taurine synthesis. In both acute and chronic liver failure - brain taurine concentrations are decreased. Taurine improves Potassium and Calcium regulation in the brain and nervous system decreasing the effects of encephalopathy. Taurine concentrations in cerebrospinal fluid in experimental acute liver failure are increased early in the progression of encephalopathy and prior to the onset of cerebral edema, a potentially fatal complication of acute liver failure. These findings suggest an osmoregulatory role for taurine in brain in acute liver failure.

  • Taurine modulates as an anti-anxiety agent in the central nervous system

  • Taurine supplementation prevents high-fat diet-induced obesity with increased resting energy expenditure. Taurine deficiency is associated with obesity and may create a vicious circle promoting obesity. Dietary taurine supplementation interrupts this vicious circle and may prevent obesity

  • Taurine is cardio-protective; reduces and prevents the incidence of cardiac arrhythmias and protects against free radicals damage. Taurine restores energy and endurance of debilitated cardiac patients

  • Taurine dampens activity of the sympathetic nervous system and dampens epinephrine release

  • Taurine protects against crush injury to brain and spinal cord (ischemia-reperfusion injury)

  • Taurine influences bone metabolism and promotes production of osteoblasts essential for non-healing fractures

  • Taurine has platelet-stabilizing and anti-hypertensive effects that reduce coronary risk and infarction

  • Taurine improves exercise time to exhaustion and maximal workload and enhances the capacity of exercise due to its cellular protective properties

  • In cases of extreme pancreatitis - histopathologic findings improved significantly after taurine supplementation

  • Elevated taurine levels in the hippocampus and caudate nucleus promotes recovery and membrane stabilization after neuronal hyperactivity and seizure activity – reduces incidence and severity of seizures

  • Both taurine and zinc provide protection of neurons against hypoxic damage

  • Taurine protects the integrity of the hepatic (liver) tissue and proves efficacious as an antioxidant in tamoxifen-induced hepatotoxicity