KEY LIFESTYLE FACTORS & SUPPLEMENTS

 

 * Hyperbaric Oxygen Therapy combined with Ketogenic Diet & deliberate lifestyle strategies reducing inflammatory cytokine expressions "rebooting" mitochondrial respiration.

Need to immediately kick start your system?

Then consider the following to re-boot your immune system and mitochondrial function, assisting to reduce the multi systemic cytokine inflammatory cascades - "autoimmune symptoms associated with Cytokine Storm".

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Importance of B3 - Nicotinic Acid - Mitochondrial activator

Ann Lab Med. 2018 Sep;38(5):395-401. doi: 10.3343/alm.2018.38.5.395.

Rejuvenating Aged Hematopoietic Stem Cells Through Improvement of Mitochondrial Function.

Mitochondria are the powerhouses of the cell as well as the primary site of hematopoiesis, which also occurs in the cytoplasm. Hematopoietic stem cells (HSCs) are characterized by a very high turnover rate, and are thus considered to be relatively free from the age-related insults generated by mitochondria. However, HSCs are also subject to these age-related insults, including the incidence of myeloid proliferative diseases, marrow failure, hematopoietic neoplasms, and deterioration of the adaptive human immune system.

 * Recently, NAD⁺ dietary supplements, known as Niacin or vitamin B₃, including tryptophan, nicotinic acid, nicotinamide, and the newly identified NAD⁺ precursor nicotinamide riboside, have been shown to play a role in restoring adult stem cell function through the amelioration of mitochondrial dysfunction.

This insight motivated a study that focused on reversing aging-related cellular dysfunction in adult mouse muscle stem cells by supplementing their diet with nicotinamide riboside. The remedial effect of nicotinamide riboside enhanced mitochondrial function in these muscle stem cells in a SIRT1-dependent manner, affecting cellular respiration, membrane potential, and production of ATP. Accordingly, numerous studies have demonstrated that sirtuins, under nuclear/mitochondrial control, have age-specific effects in determining HSC phenotypes. Based on the evidence accumulated thus far, we propose a clinical intervention for the restoration of aged HSC function by improving mitochondrial function through NAD⁺ precursor B3 supplementation.

HBOT plus key supplements assisting Mitochondrial immune modulation

 * Ketogenic (intermittent fasting) combined with Cytokine modulators.

Alkalinity

 * Rapid elevation of circulating ph reducing inflammatory cytokines - assist to "flush out" expelled inflammatory cytokines.

Ketogenic Diet

 * Therapeutic ketosis can be used to treat a wide variety of immunosuppressive disorders linked to metabolic dysregulation.

 * Cancer is metabolic dysregulation and is responsive to metabolic therapies that lower blood glucose and elevate blood ketones.

 * Cancer cells require glucose to survive and lack the ability to derive energy from ketones due to mitochondrial defects.

 * Ketosis promotes anti-inflammatory and anticatabolic effects prevent muscle wasting associated with aging, cancer and motor neuron diseases.

 * Elevated circulating Ketones reduce neuronal hyperexcitability, oxidative stress and enhances brain metabolism.

KetoBlitz 

 * Ketone Supplement - elevate circulating BHB or beta-hydroxybutyrate which elevates immune responses including brain derived neurotrophic factors (BDNF) and other reparative anti-inflammatory gene expressions.

BPC157​​

 * Shown to benefit ulcers in the stomach, intestinal damage such as fistulas and inflammatory disorders, bone and joint healing and growth rates, and organ damage.

 ** It also has some influences on the brain. Researchers have observed marked protective effects when BPC-157 is administered to rats alongside a research toxin or damaging surgical procedure.

 

Brain Octane Oil

 * Caprylic Acid Triglycerides. Recommended with KetoBlitz to elevate BHB or beta-hydroxybutyrate.

 

Beetroot Juice

 * Nitrous Oxide stimulant - elevates circulating red blood cells.

Cannabis

 * Cytokine modulation.

 

Curcumin

 * Reduces gut, brain inflammation specifically Il1, Il6, Il8

 

Cytokine Therapy

 * www.guna.com (interleukins) - GM-CSF, IL4, IL10, IL13 taken sublingual. 

 

Euphorbia Kansui

 * Euphorbia kansui effectively reduced the expression of inflammation related cytokines, such as NF-κB, TNF-α, sTNFR, IL-6, and IL-8, in the serum of patients with severe acute pancreatitis.

 ** It was also proposed that euphorbia kansui hindered the release of inflammatory factors and treated SAP by inhibiting the activation of the NF-κB signaling pathway.

FTY720

 * FTY720 decreased the severity and abolished the chronicity of the disease.

 ** Therapeutic FTY720 treatment reversed electrophysiological and histological anomalies, suggesting that myelinated fibers were subsequently preserved, it inhibited macrophage and IL-17+ cell infiltration in PNS, and it significantly reduced circulating pro-inflammatory cytokines.

Fatostatin

 * Fatostatin blocks adipogenesis by inhibiting the activation of SREBPs (Sterol Regulatory Binding Proteins) LINKED with obesity, tumor growth, elevated PSA in males.

 ** Fatostatin prevents increases in body weight, blood glucose and hepatic fat accumulation in obese mice.

Gastrodin 

 * Broad Spectrum Protection Against Brain Aging - plant based stimulant to BDNF (Brain Derived Neurotrophic Factors).

Low Dose Naltrexone

 * Script required - 4.5mg taken at night. Assists to "reset" the cytokine imbalance and modulate the "Cytokine Storm".

 

MCT Powder 

 * (Medium Chain Triglyceride Powder) - supplement assists to keep the body in a circulating ketone state.

 

Metformin

 * Script required - 500mg twice daily. Inhibits absorption of glucose and blocks Interleukin 8 & TNFa at the gut level.

 

MethylsulphonylMethane (MSM)

 * Excellent for joint and connective tissue support.

N-Acetyl Cysteine (NAC)

 * Penetrates blood brain barrier (BBB) inhibiting cytokine inflammation (IL1, Il6, Il7, Il8, Il17, TNFa, S100B etc).

 

Nicotinamide Riboside (NAD+ precursor) 

 * Activates mitochondrial function and respiration.

 

Parthenolide - (Feverfew

 * Reduces NFkB and ability of cancer cells to proliferate and metastasis to bone.

 

Sodium Bicarbonate

 * Changes blood ph from acidosis to alkalinity.

 

Synext (Nicotinic Acid)

 * The vitamin plays a role in both neuroprotection and neuronal death, giving it utmost importance in the proper functioning of the central nervous system (CNS), neuronal development, and function.

Taurine

 * Strong neuroprotection and regeneration following injury.

 

Vitamin D

 * Vitamin D (10,000IU) has potent immunomodulatory effects on neurodegenerative conditions including MS, stroke and other brain neurodegenerative disorders. Vitamin D increases immune responsive interferon (IFN)-γ, Interleukin-10 & IL-17 which are powerful anti-inflammatory 'reparative' interleukins assisting autoimmune inflammatory disorders.