LYME LIKE ILLNESS & OTHER CHRONIC INFECTIONS

Caveat

  • The following list provides a 'knowledge share base' working to collaborate and promote the benefits of Hyperbaric Oxygen Therapy.

  • Australia is not a leader in this field but lagging behind the rest of the world in relationship to the wider applications of modern Hyperbaric Oxygen Therapy using different 'pressure protocols for different conditions'. 

  • The information provided does not constitute a medical endorsement or recommendation. It is intended for informational purposes only, and no claims, either real or implied, are being made. 

 

 

Are your symptoms due to Lyme Infection or are they due to Cytokine Storm symptoms?

  • Most patients with chronic lyme like illness are 'correctly' informed that they have 'marginal blood results for Lyme infections' meaning they are either 'borderline positive' or 'equivocal finding'.

  • In the absence of something more concrete the patient is informed they have "Lyme Disease".

  • This may not be the case. 

  • So why the chronic and progressive and often debilitating symptoms?

 * Chronic 'Cytokine Storm' symptoms associated with an overproduction of proinflammatory cytokines due to chronic tissue hypoxia.

  • No doubt chronic infections thrive in a 'low oxygen' (hypoxic) environment however what is the true basis of your symptoms?

  • Hyperbaric Oxygen Therapy works because it creates an oxidative response at a cellular level. This oxidative stress is well documented and is the basis of ALL HBOT applications.

  • HBOT at too high a pressure will result in a heightened and dramatic "washout" effect at a cellular level, which is referred to as a Herxheimer reaction. The cellular washout (herxheimer's reaction) is common with all patients including high level athletes however, too high a HBOT pressure will produce dramatic and often overwhelming effects on the patient depending on the level of the Cytokine Storm state.

  • For the athlete, too high a pressure will make the athlete feel very flat with flu like symptoms for the next 24-48 hours. This is not what is wanted particularly if the athlete is attending for HBOT whilst competing at high international standards.

  • The 'wash out' effect is commonly observed and can be clearly documented with proper testing - before HBOT and interval cytokine blood testing.

  • If you have a chronic Lyme related illness then the first step is to get a full cytokine biomarker testing.

 

  • Most Lyme patients are suffering the effects of elevated Interleukin 1, 6, 7, 8, TNFalpha, S100-B etc. The issue is that the body immune system is 'attacking' itself and not the Lyme which like most infections may be part of the body's natural 'ecosystem' as we are all carrying billions of 'unique' bugs in our system.

  • Hyperbaric Oxygen Therapy pressure at 1.8-2.0 ATA are effective and will modulate the cytokines in a safe and controlled way.

  • In fact, we have over 20- years experience treating individuals with chronic Lyme symptoms and a host of other infections including mycoplasmas, rickettsias, chlamydias, epstein barr, cytomegalovirus, MARCONs, molds etc. The list is endless ...

  • Chronic infections including cancers cause havoc to the mitochondrial function and subsequently the compromised mitochondria 'pumps out' excessive inflammatory cytokines - this is the basis of 'autoimmune illness' - your body is attacking itself.

 

  • The combination effects of hypoxia, excessive production of pro-inflammatory interleukins, TNFα, co-infections, hi glucose & carbohydrate diet all contribute to the metabolic state referred to as the Cytokine Storm - the precise FUEL for chronic Lyme and co-infections.

 

For more information go to Cytokine Biomarkers.

You are most welcome to contact us for further information.

Key Lifestyle Factors To Diminish Cytokine Storm Symptoms

 

Summary Benefits Of Hyperbaric Oxygenation

 

  • HBO accelerates immune responses.

  • HBO is non-invasive.

  • HBO increases Oxygen tension into Hypoxic tissue inhibiting opportunistic infections and cellular mutations.

  • Professor Paul Harch 2015 reports 'As many as 8101 genes were either up- or down-regulated over 24 h after a single exposure to HBOT'. Up~Regulated genes were primarily growth and repair hormones and the anti-inflammatory genes; Down~Regulated genes were the pro-inflammatory and apoptotic genes'  

HBO effects on chronic Traumatic Brain Injury: Oxygen, Pressure, Gene Therapy

  • HBO Up~Regulates the patients own target specific Stem Cells {an 8-fold (800%) increase in circulating CD34+}; HBO enhances Mitochondrial function, HBO proliferates Vascular Endothelial Growth Factors (VEGF) & Neural Growth Factors (BDNF & GDNF), HBO reduces Telomeres degeneration and more 

 

  • HBO Down~Regulates toxic intra and extra cellular inflammatory Cytokines (IL1, 2, 6, 7, 8), Tumour Necrosis Factor Alpha (TNFα), chronic opportunistic Anaerobic (MRSA, VRE) and co-infections (Viral, Bacterial, Parasitic), Cell Sepsis and more ...

  • HBO is the 'integrative bridge' between orthodox medicine and complementary approaches.

  • Oxygen is essential to quality of life and essential to drug delivery.

  • This multifactor internal healing response is 'unique' to Hyperbaric Oxygenation.

Key Factors Driving Chronic Lyme Infection Resistance:

 

  • Hypoxia (low oxygen tension is the hallmark of deep seated chronic illness and infections); inflammatory cytokines (intracellular/extracellular 'soup' ~ referred to as a Cytokine Storm), resistant cellular biofilm (rendering antibiotics ineffective); elevated tumour necrosis factor alpha; chronic anaerobic co-infections, fungal infections; high glucose diet ...

  • The combination effects of hypoxia, inflammatory interleukins, TNFα, co-infections, hi glucose & carbohydrate diet all contribute to the metabolic state referred to as the Cytokine Storm - the precise FUEL for chronic Lyme and co-infections.

Chronic Symptoms Associated With A Cytokine Storm & Lyme Like Disorders

 

  • Fatigue, Weakness, Aches, Muscle Cramps, Unusual Pain, Ice Pick Pain, Headache, Light Sensitivity, Red Eyes, Blurred Vision, Tearing, Sinus Problems, Cough, Shortness of Breath, Abdominal Pain, Diarrhea, Joint Pain, Morning Stiffness, Memory Issues, Focus/Concentration Issues, Word Recollection Issues, Decreased Learning of New Knowledge, Confusion, Disorientation, Skin Sensitivity, Mood Swings, Appetite Swings, Sweats (especially night sweats), Temperature Regulation or Dysregulation Problems, Excessive Thirst, Increased Urination, Static Shocks, Numbness, Tingling, Vertigo, Metallic Taste, Tremors.

  • Cytokine Storm Symptoms Severity Form (to be completed pre_HBO and at regular intervals in conjunction with Cytokine profile blood tests).

What is Lyme infection? Tick Bite

 

  • Following the tick bite an erythema migrans or 'bull's eye' rash typically develops several days or weeks later which is capable of expanding up to 30cm across.

  • An array of flu like symptoms referred to as part of the emerging Cytokine Storm appears weeks to months the most common are joint swelling and fibromyalgia symptoms similar to inflammatory arthritis and potentially progresses over years leading to chronic health illness. 

  • Unfortunately as many as half of bitten individuals do not notice the bite and the rash itself may not appear at all (Edlow 2002, Stricker & Phillips 2003)

 

Lyme Testing is NOT a standard blood test

Nutripath Lyme Profile

  • Lyme Disease Immunoserology Panel Test Code: 3411 (Borrelia burgdorferi (IgG & IgM), OspA+OspC peptides (IgG & IgM), OspE peptide (IgG & IgM), Leukocyte Function Associated antigen (IgG & IgM), Immunodominant protein (IgG & IgM), Variable Major protein (IgG & IgM); Borrelia b. sensu stricto (IgG & IgM), B. garinii (IgG& IgM), B.afzelii (IgG & IgM); Babesia (IgG & IgM), Ehrlichia (IgG & IgM), Bartonella (IgG & IgM).

  • Lyme Disease Immunoserology and Western Blot Panel Test Code: 3412 - Lyme Specific Abs, Borrelia sub-species Abs, Lyme co-infection Abs [as per 3411] AND Borrelia burgdorferi IgG & IgM (by Western Blot)

 

Australian Biologics Testing Services

  • Australian Biologics Lab is based in Sydney and relies on DNA testing using Polymerase Chain Reaction (PCR) technology to detect certain pathogenic and opportunistic microorganisms present in blood, urine and tissue.  Referral form - aus-biologics-practitioner-referral-form.pdf

Nutripath Cytokine Panel

http://nutripath.com.au/product/cytokine-panel-level-1-code4003-cytokine-panel-level-2-code4005-blood-spot/

  • Cytokine Panel Test: Interleukin-1 (IL1), Interleukin-2 (IL2), Interleukin-4 (IL4), Interleukin-5 (IL5), Interleukin-6 (IL6), Interleukin -7 (IL7), Interleukin-8 (IL8), Interleukin-10 (IL10), Interleukin-13 (IL13), interferon-gamma (INFγ), Tumour necrosis factor alpha (TNFα), Tumour necrosis factor beta (TNFβ),  Transforming growth factor beta (TGFβ).

 

  • Cytokines are chemical messengers that primarily signal the immune system and also play a role as neuromodulators. They can be defined as either pro-inflammatory or anti-inflammatory. Cytokine imbalances are known to be involved in autoimmune disorders, atopic conditions as well as neuropsychiatric disorders.

  • Cytokines are signalling proteins and glycoproteins that 'orchestrate' (mediate) immunity, inflammation and hematopoiesis. They are also involved in cell growth and differentiation, cell death, angiogenesis, normal development and neuromodulations. 

 

  • Cytokines interleukin 6 (IL6) can increase up to a 1,000-fold during trauma and chronic infection.

  • Cytokines are critical to the functional both innate (cell-mediated) and adaptive (antigen specific/humoral) immune systems. They are known as either pro-inflammatory or anti-inflammatory. 

 

  • Pro-inflammatory cytokines include interleukin-1 (IL1), interleukin-2 (IL2), interleukin-6 (IL6), interleukin-7 (IL7), interleukin-8 (IL8)  and interleukin-12 (IL12).

  • Anti-inflammatory cytokines include: interleukin-4 (IL4), interleukin-5 (IL5) and interleukin-10 (IL10) and interleukin-13 (IL13).

  • Tumour Necrosis Factor is a master regulator of inflammation and associated with multiple autoimmune inflammatory disorders and disease processes.

  • Interferon-gamma (INFγ) is often elevated in response to anti TNF therapies.

  • The combination effects of hypoxia, inflammatory interleukins, TNFα, co-infections, hi glucose & carbohydrate diet all contribute to the metabolic state referred to as the Cytokine Storm - the precise FUEL for chronic Lyme and co-infections.

Cytokine Storm - The Perfect Storm

Small Start - Systemic Spread

Immune Confusion - The Body Attacks Itself

TNF Accumulates At Site Of Injury Driving Pain

TNF Accumulates In The Hippocampus & Linked With Chronic Neuropathic Pain, Depression, Mental Health, Brain Degeneration. TNF Inhibits Neuroplasticity

Excess Of Inflammatory Cytokines

TNF - Master Regulator Of Inflammation Cascade

Cytokine Storm Cascade

TNF Linked With All Disease

Cytokine Storm Leads To Cytokine Shock - Immune Self Abuse - Tissue & Organ Destruction

Effects Of Long Term Antibiotics

 

  • Have you taken LONG TERM Antibiotics with a honeymoon period feeling better THEN gotten progressively worse?

  • There is a strong move internationally towards short-term cyclic antibiotics and; away from ongoing medications including antibiotics. The reason is that chronic infections have the capacity to adapt and mutate developing strong antibiotic resistance. Antibiotics also cause cytokine and interleukin irregularities.

  • Many commonly prescribed Antibiotics for Lyme and co-infections MOSTLY elevate inflammatory cytokines contributing to Cytokine Storm symptoms.

  • If you are taking antibiotics, then ask your doctor to trial Minocycline which elevates IL10, IL4, IL15 (pro anti-inflammatory cytokines - 'good guys')

Minocycline modulates cytokine and gene expression profiles in the brain after whole-body exposure to radiation.

Mehrotra S1, Pecaut MJ, Gridley DS.

Author information - Chan Shun Pavilion, Room A-1010, 11175 Campus Street, Loma Linda University, Loma Linda, CA 92354, U.S.A. dgridley@llu.edu.

Abstract

An effective countermeasure against radiation damage to normal tissues is urgently needed. The major goal of the present study was to determine if minocycline could modify the immunomodulatory effects of radiation on the brain. C57BL/6 mice were treated with minocycline intraperitoneally for 5 days beginning immediately before total-body exposure to 0, 1, 2 and 3 Gray (Gy) (60)Co γ-rays. Brains were collected on days 4 and 32 post-irradiation for cytokine and gene analyses.

Minocycline treatment significantly increased the levels of interleukin (IL)-10, IL-15 and vascular endothelial growth factor (VEGF) in the brain on day 4 in one or more irradiated groups compared to radiation-alone (p<0.05).

  • IL-10 is anti-inflammatory, IL-15 can prevent apoptosis and VEGF is neuroprotective.

On day 32, the drug decreased IL-1β in the 2- Gy group (p<0.05 vs. 2-Gy alone); this cytokine is implicated in immune-related central nervous system pathologies. Microarray analysis of brains on day 32 showed that while radiation increased expression of inflammatory genes such as Il1f10, Il17, Tnfrsf11b, Tnfsf12, Il12b and Il1f8, these were no longer up-regulated in the minocycline-treated groups.

Similarly, the pro-apoptotic gene Bik and nitric oxide synthase producer (Nostrin) were no longer up-regulated in the drug-treated groups. Pathway analysis based on gene data suggested that catenin-β1 and tumor suppressor-related transcription regulation were significantly activated by radiation and/or minocycline (activation z-score >2.0).

Overall, the data warrant further testing of minocycline as a potential neuroprotectant against radiation-induced damage.