Interleukin-5 | IL5

  • Alias: Interleukin-5, B-cell differentiation factor I, T-cell replacing factor

  • IL-5 is a TH2 cytokine that acts as a hematopoietic growth factor that promotes proliferation, activation, and differentiation of eosinophils from bone marrow stem cells.

  • In the human, IL-5 also supports generation of cytotoxic T cells, whereas in mice, IL-5 acts on B cells to induce IL-2R (CD25) expression on activated B cells, proliferation and secretion of IgM and IgA from endotoxin activated B cells.

  • IL5 is a potent T-cell derived factor that stimulates the growth of certain B cells and the differentiation of eosinophils. Human IL-5 is a 26.5 kDa protein containing 232 amino acid residues.

  • Targeting Interleukin (IL) 5 for Asthma and Hypereosinophilic Diseases