Interleukin-4 | IL4

  • Alias: Interleukin-4, B-cell stimulatory factor 1

  • IL-4 is a TH2 anti-inflammatory cytokine that is secreted by activated TH2 and NKT cells, and to a lesser extent by TH1 and mast cells. IL-4 exerts numerous effects on various hematopoietic cell types by biding to either type I or Type II IL-4R (the latter of which IL-13 also binds to and as such is also referred to as IL-13R). IL-4, by the means of STAT6 and GATA3, promotes TH2 cell differentiation that produces IL-4, IL-5, and IL-13. In B cells, IL-4 promotes proliferation and differentiation, promotes immunological class switching to IgE and IgG1 isotypes (in conjunction with other signals such as CD40), and upregulates MHC class II and CD23 expression.

  • In T and B lymphocytes, mast cells, and endothelial cells, IL-4 promotes survival, growth, and differentiation. In macrophages, IL-4 can inhibit the production of TNF, IL-1, and IL-6. With its relevance to disease, IL-4 is an immune-stimulating molecule. As such it is one of the more recent targets being studied for new asthma treatments.

  • IL4 is a pleiotropic cytokine and a potent lymphoid cell growth factor that stimulates the growth and survivability of certain B cells and T cells. It is produced by activated T cells and is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. 

  • IL-4 has striking antitumor activities raise the possibility that IL-4 or potential small molecule agonists may be potent biologic agents to enhance immune elimination of certain tumor cells.

  • IL-4 ameliorates non-resolving neuro-inflammation that causes neuropathic pain after nerve injury (crush injury).

  • It is closely related and has functions similar to Interleukin 13.

  • Interleukin-4: A Prototypic Immunoregulatory Lymphokine

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