AUTISM & CHILDHOOD DEVELOPMENT DELAY

Caveat

  • The following list provides a 'knowledge share base' working to collaborate and promote the benefits of Hyperbaric Oxygen Therapy.

  • Australia is not a leader in this field but lagging behind the rest of the world in relationship to the wider applications of modern Hyperbaric Oxygen Therapy using different 'pressure protocols for different conditions'. 

  • The information provided does not constitute a medical endorsement or recommendation. It is intended for informational purposes only, and no claims, either real or implied, are being made. 

OXYMED Case Study DC age 7 Autism

  • Cytokine Testing pre-HBOT, then 70-hours HBOT and again at 120 hours HBOT.

- High functional autism, non-social, non-verbal, 

  • Typically between 50-70 hours of HBOT, there is a "washout" of inflammatory cytokines followed by reduction of the inflammatory markers corresponding with notable elevation of anti-inflammatory cytokines including BDNF (Brain Derived Neurotrophic Factor).

- Significant improvement, global executive functioning, talking, responsive, drawing and reading.​

Autism, Cerebral Palsy, Infantile Stroke, Near Drowning, Delayed Development Syndrome, Behavioral and Learning Difficulties, Compulsive Obsessive Disorders, Motor Skill Delay ...

 

 * This is not an anti vaccination position.

 ** The 'at risk' child - be 'properly informed'.

Are ALL vaccines safe?

 * What does the manufacturer state in their CMI?

PRIORIX® Measles-Mumps-Rubella vaccine live

CONSUMER MEDICINE INFORMATION LEAFLET 

BEFORE RECEIVING PRIORIX

DO NOT HAVE PRIORIX IF

 * You have or your child has lowered immunity.  

This can occur in persons:

 - with inherited (or family history of) immune deficiency conditions

 - with abnormal blood conditions or blood protein (immunoglobulin) disorders (addition - Cytokines and other Glycoproteins)

 - with cancer

 - receiving or who have received certain drugs (i.e. cyclosporin, corticosteroids, and cancer medicines)

 - receiving or who have received radiation therapy 

 

WHEN IT WILL BE GIVEN

 * The first dose of PRIORIX is generally given to children at 12 months of age.  

 ** A second dose is then administered to children at 4-6 years of age - preferably before commencement at school.

SIDE EFFECTS 
Tell your doctor, nurse or pharmacist as soon as possible if you (or your child) have troublesome symptoms after having had a dose of PRIORIX.

 

PRIORIX helps protect most people from measles, mumps and rubella infection, but it may have unwanted side effects in a few people.  

All medicines and vaccines can have side effects. Sometimes they are serious; most of the time they are not. Some side effects may need medical treatment.  The chance of your child having a serious side effect is very much less than the chance of you or your child having a permanent injury from the natural infections.

Ask your doctor, nurse or pharmacist to answer any questions you may have.

Most unwanted effects with PRIORIX are mild.

These effects, as with other vaccines, generally occur around the injection site.  

Side effects that occurred during clinical trials with PRIORIX were as follows:

 * Very common (these may occur with more than 1 in 10 doses of the vaccine):

 • pain and redness at the injection site

 • fever greater than or equal to 38°C (rectal)

 

 ** Common (these may occur with up to 1 in 10 doses of the vaccine):

 • swelling at the injection site

 • fever greater than 39.5°C (rectal)

 • rash (spots and/or blisters)

 • upper respiratory tract infection

 • infection of the middle ear

 • viral infection

 • nervousness

 • bronchitis

 • cough

 • runny nose

 • diarrhoea

 • vomiting

 • headache

 • sore throat and discomfort when swallowing    

 

 *** Uncommon (these may occur with up to 1 in 100 doses of the vaccine):

 • allergic reactions

 • tiredness (fatigue)

 • swelling of the mouth and throat

 • toothache

 • loss of appetite

 • nausea

 • abnormal crying

 • not being able to sleep (insomnia)

 • discharge with itching of the eyes and crusty eyelids (conjunctivitis)

 • swollen glands in the cheek

 • swollen glands in the neck, armpit or groin

 • itchiness

 • cold sores, shingles

 • feeling generally unwell, dizziness, tiredness

 • harsh breathing sounds

 • pneumonia

 • nose bleeds

 • stomach pain or discomfort

 • dizziness

 

 **** Rare (these may occur with up to 1 in 1,000 doses of the vaccine):

 • seizures with fever. 

 

After commercialisation, the following additional side effects have been rarely reported in people vaccinated with PRIORIX:

 • mumps like symptoms (including transient, painful swelling of the testicles and swollen glands in the neck)

 • temporary lumpy rash that may affect the skin, mouth and other parts of the body

 • bleeding or bruising more easily than normal which may be associated with skin rashes/peeling or fever

 • joint and muscle pains

 • infection around the brain or spinal cord (meningitis)

 • infection or inflammation of the nervous system resulting in temporary loss of control of bodily movements, walking or sensation changes

 

Other side effects not listed above, can also occur during or soon after a dose of PRIORIX

MMR snip.PNG
Why Breast Is Best

Digested Early Preterm Human Milk Suppresses Tumor Necrosis Factor-induced Inflammation and Cytotoxicity in Intestinal Epithelial Cells.

J Pediatr Gastroenterol Nutr 2018 Feb 21. Epub 2018 Feb 21.

University of Illinois at Chicago, Chicago, IL.

  • February 2018

 

Objectives: The aim of this study was to determine the effect of digested whole human milk (HM; first sample available after birth from mothers of premature infants) on inflammation, oxidative stress, and cytotoxicity in Caco-2 human intestinal epithelial cells stimulated with lipopolysaccharides or tumor necrosis factor (TNF) to mimic the potential in vivo insults facing the premature infant's gastrointestinal tract.

Methods: Fully differentiated Caco-2 cells were exposed to digested HM (n = 10; samples from 10 different individuals) before stimulation with lipopolysaccharides, TNF, or no stimulation overnight. Inflammation was determined by production of interleukin-8, oxidative stress by levels of F2-isoprostane, and cytotoxicity by released lactate dehydrogenase.

Results: HM significantly suppressed interleukin-8 production and cytotoxicity in TNF-stimulated cells, while also suppressing cell death under baseline conditions. Individual HM samples differed widely in their ability to modulate cellular responses.

Conclusions: Results from this study provide evidence that digested HM can reduce both an exaggerated inflammatory response and intestinal damage that contribute to the pathogenesis of necrotizing enterocolitis.

Maternal Immune Issues

Is YOUR child at risk because of underlying maternal immune issues?

 

Mol Psychiatry. 2016 May 24. doi: 10.1038/mp.2016.77. [Epub ahead of print]

Autism with intellectual disability is associated with increased levels of maternal cytokines and chemokines during gestation.

Jones KL1,2, Croen LA3, Yoshida CK3, Heuer L1,2, Hansen R2,4, Zerbo O3, DeLorenze GN3, Kharrazi M5, Yolken R6, Ashwood P2,7, Van de Water J1,2.

Author information

Abstract

Immune abnormalities have been described in some individuals with autism spectrum disorders (ASDs) as well as their family members. However, few studies have directly investigated the role of prenatal cytokine and chemokine profiles on neurodevelopmental outcomes in humans. In the current study, we characterized mid-gestational serum profiles of 22 cytokines and chemokines in mothers of children with ASD (N=415), developmental delay (DD) without ASD (N=188), and general population (GP) controls (N=428) using a bead-based multiplex technology. The ASD group was further divided into those with intellectual disabilities (developmental/cognitive and adaptive composite score<70) (ASD+ID, N=184) and those without (composite score⩾70) (ASD-noID, N=201). Levels of cytokines and chemokines were compared between groups using multivariate logistic regression analyses, adjusting for maternal age, ethnicity, birth country and weight, as well as infant gender, birth year and birth month.

  • Mothers of children with ASD+ID had significantly elevated mid-gestational levels of numerous cytokines and chemokines, such as granulocyte macrophage colony-stimulating factor (GM-CSF), interferon-γ, interleukin-1α (IL-1α) and IL-6, compared with mothers of children with either ASD-noID, those with DD, or GP controls. Conversely, mothers of children with either ASD-noID or with DD had significantly lower levels of the chemokines IL-8 and monocyte chemotactic protein-1 compared with mothers of GP controls. This observed immunologic distinction between mothers of children with ASD+ID from mothers of children with ASD-noID or DD suggests that the intellectual disability associated with ASD might be etiologically distinct from DD without ASD.

  • These findings contribute to the ongoing efforts toward identification of early biological markers specific to subphenotypes of ASD. Molecular Psychiatry advance online publication, 24 May 2016; doi:10.1038/mp.2016.77.

J Trace Elem Med Biol. 2016 Mar;34:32-7. doi: 10.1016/j.jtemb.2015.12.002. Epub 2015 Dec 4.

Iodine in autism spectrum disorders.

Błażewicz A1, Makarewicz A2, Korona-Glowniak I3, Dolliver W4, Kocjan R4.

Author information

Abstract

OBJECTIVE:

The aim of our study was to assess the iodine status of Polish boys with severe autism compared to their healthy peers and evaluate the relationship between urinary iodine, thyroid hormones, body mass index and Autism Spectrum Disorder (ASD) symptomatology.

SUBJECTS AND METHODS:

Tests were performed in 40 boys with ASD and 40 healthy boys, aged 2-17 from the same geographic region in Poland. Urinary iodine (UI), free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH), BMI, and individual symptoms measured by the Childhood Autism Rating Scale (CARS) were correlated. Validated ion chromatography method with pulsed amperometric detection was applied for the determination of urinary iodine after optimized alkaline digestion in a closed system assisted with microwaves.

RESULTS:

19 out of 40 children with ASD had mild to moderate iodine deficiency. Statistically significant lower levels of UI, fT3 and fT4 and higher levels of TSH were found in the autistic group when compared with the control group. Concentration of iodine in urine was negatively associated with clinician's general impression for children between 11 and 17 years. Emotional response, adaptation to environmental change, near receptor responsiveness, verbal communication, activity level, and intellectual functioning are more associated with UI than other symptoms listed in CARS.

CONCLUSION:

The severity of certain symptoms in autism is associated with iodine status in maturing boys. Thyroid hormones were within normal reference ranges in both groups while urinary iodine was significantly lower in autistic boys suggesting that further studies into the nonhormonal role of iodine in autism are required.

Arch Med Res. 2013 Oct;44(7):555-61. doi: 10.1016/j.arcmed.2013.09.012. Epub 2013 Oct 10.

Iodine deficiency in Egyptian autistic children and their mothers: relation to disease severity.

Hamza RT1, Hewedi DHSallam MT.

Author information

Abstract

BACKGROUND AND AIMS:

Because autism may be a disease of early fetal brain development, maternal hypothyroxinemia (HT) in early pregnancy secondary to iodine deficiency (ID) may be related to etiology of autism. The aim of the study was to assess the iodine nutritional status in Egyptian autistic children and their mothers and its relationship with disease characteristics.

METHODS:

Fifty autistic children and their mothers were studied in comparison to 50 controls. All subjects were subjected to clinical evaluation, measurement of urinary iodine (UI), free triiodothyronine (fT3), free tetraiodothyronine (fT4) and thyroid-stimulating hormone (TSH) along with measurement of thyroid volume (TV). In addition, electroencephalography (EEG) and intelligence quotient (IQ) assessment were done for all autistic children.

RESULTS:

Of autistic children and their mothers, 54% and 58%, respectively, were iodine deficient. None of the control children or their mothers was iodine deficient. UI was lower among autistic patients (p <0.001) and their mothers (p <0.001). Childhood Autism Rating Scale (CARS) score correlated negatively with UI (r = -0.94, p <0.001). Positive correlations were detected between autistic patients and their mothers regarding UI (r = 0.88, p <0.001), fT3 (r = 0.79, p = 0.03), fT4 (r = 0.91, p <0.001) and TSH (r = 0.69, p = 0.04). Autism had a significant risk for association with each of low UI (OR: 9.5, 95% CI: 2.15-33.8, p = 0.02) and intake of noniodized salt (OR: 6.82, 95% CI = 1.36-34.27, p = 0.031).

CONCLUSIONS:

ID is prevalent in Egyptian autistic children and their mothers and was inversely related to disease severity and could be related to its etiology.

Environ Health Perspect. 2008 Apr;116(4):A155. doi: 10.1289/ehp.11010.

The interaction of agricultural pesticides and marginal iodine nutrition status as a cause of autism spectrum disorders.

Sullivan KM.

Comment on

Case Study JP age 7

Birth Hypoxia (Peri Ventricular Leukomalacia), Severe Autism Spectrum Disorder, Development Delay, Severe Oral Aversion, Moderate Kidney Failure

  • Young Jamie has a multitude of problems with an extensive medical history including orthodox, alternative and integrative medical approaches.

  • After the initial 40-60 hours of HBO (HBO 2ATA 100%O2) his mother (registered dentist) presented a series of dramatic drawings and pictures by Jamie.

  • Jamie's mother stated that the drawings were done immediately after his time in the HBO chamber whilst travelling back to the family home.

  • You will note these are the 'Regulatory Warning' prior to watching the DVD movie. Jamie's mother says she has also checked the 'numbers' on Jamie's drawings and the numbers are correct.

 

 ** Extraordinary!   Perhaps Jamie is a 'savant'?

Does Rubella cause Autism 2015 Reapprais

Study the effect of hyperbaric oxygen therapy in Egyptian autistic children: A clinical trial (2014)

Egyptian Journal of Medical Human Genetics

Volume 15, Issue 2, April 2014, Pages 155–162

  • Numerous studies of autistic individuals have revealed evidence of cerebral hypoperfusion, neuroinflammation, gastrointestinal inflammation, immune dysregulation, oxidative stress, relative mitochondrial dysfunction, and neurotransmitter abnormalities. Many of these findings have been correlated with core autistic symptoms.

  • For example, cerebral hypoperfusion in autistic children has been correlated with repetitive, self-stimulatory and stereotypical behaviors, and impairments in communication.

  • What Are Cytokines?

Conclusion

  • Hyperbaric Oxygen Therapy is a treatment that has recently become quite popular in the autism spectrum disorder (ASD) community. Its benefits cross a wide range of autistic traits as: improved language, increased awareness, behavior and socialization by affecting the pathophysiological findings in autism.

Case Study MM age 6 Severe Autism Spectrum Disorder, Non-Verbal

Parent Experience

'Hi M (HyperMED),

Just some update 3 months later.

Michael now repeats 216 words after us and actively uses 7 short phrases or words to ask us to do something. He is now learning a short poem of 20 words. This poem is for just 5 last days and he did huge progress. 

On Saturday we purchased him a new puzzle - have a look at 2 pictures in the attachment. This is a 300 pieces puzzle and the box shows that this is for 9+ years old children (Michael is 7 now). He did all by himself!

Regards,

S (Father MM)'

"Hi HyperMED,

It took us quite some time to write it down but at last we put some story as requested.

We did 100 hours of oxygen for our son Michael. We started when he was 6 years old.  It took us 3 months to finish 100 hours. We started in early January 2014 and finished on the first or the second day of April. We did 10 hours a week on the average.

The first thing we noticed was in around a month and a half after we started. Michael looked apparently bigger and heavier. Holding his hand, it was obvious that his palm became noticeably wider and stronger. We did not check his weight in the beginning but we think that he gained up to 5 kg during those 3 months, from approximately 25 (26 top) to 30 kg.

At around that time we started noticing that it took him much less time to do his usual home exercises (puzzles, threading, nuts and bolts etc). Unfortunately we could not do much practice with him during those 3 months as along with other family responsibilities oxygen took all our time.

We remember an interesting case in the middle of doing the oxygen therapy. It was not too warm and we walked at the beach. Michael as usual tried to run to the water which would be too cold now. Usually we had to just run and catch him before he is all wet. This time shouting to stop was enough. He started running towards water many times but when we shouted something like 'Stop!' he had never go further than half a distance (15-20m) between us and water. That was a remarkable change. 

He still did not start speaking by the end of the oxygen therapy.

We started a different therapy very soon after finishing oxygen. In maybe 2 months after that Michael started repeating single words after us. That never happened before and was a very big thing for us. As with other things we did we are not sure which therapy made the change. We tend to think it's a combination. However while we were still  doing oxygen hours, MH said that it often takes 2-3 months for changes to sort of 'propagate' and children to start speaking. What happened with us fits MH's words perfectly.

It's early November, 2014 and Michael can repeat about 70 words after us. Pronunciation for some worlds is perfect but for some is barely recognizable. He has problems with some sounds and he does not use words for communication yet.

Last 4 months we gave him a lot of new puzzles. Those puzzles are 50, 100, 150 or 200 pieces each. He did all his puzzles on his own. Doing new 200 pieces puzzles took him only 2, maybe up to 3 hours. Well, when he was not being lazy. We attach some puzzle pictures, they are great.

Michael had quite some progress this year. The biggest problem is probably his behaviour now. It improved a bit during the oxygen therapy but became much worse during the year. This is especially frustrating because we see that Michael is a much brighter and clever now. We are seeking for ways to fix it. Homeopathy might be the answer.

We are very grateful to you, MH. Your therapy is great. You are great yourself. You are one of the most interesting people we met this year. Thanks a lot for what you are doing!

Regards,

S and S (Parents of MM)"

Study the effect of hyperbaric oxygen therapy in Egyptian autistic children: A clinical trial (2014)

Egyptian Journal of Medical Human Genetics

Volume 15, Issue 2, April 2014, Pages 155–162

Numerous studies of autistic individuals have revealed evidence of cerebral hypoperfusion, neuroinflammation, gastrointestinal inflammation, immune dysregulation, oxidative stress, relative mitochondrial dysfunction, and neurotransmitter abnormalities. Many of these findings have been correlated with core autistic symptoms. For example, cerebral hypoperfusion in autistic children has been correlated with repetitive, self-stimulatory and stereotypical behaviors, and impairments in communication.

Specifically, hyperbaric oxygen therapy (HBOT) has been used and can compensate for decreased blood flow by increasing the oxygen content of plasma and body tissues. The aim of this work was to study the effect of hyperbaric oxygen therapy in autistic Egyptian children.

Patients and methods

This prospective clinical trial study was conducted on 20 children diagnosed as autism based on DSM-IV-TR criteria (diagnostic and statistical manual of mental disorders, 4th edition criteria, text revised). All patients received at least 20 sessions of hyperbaric oxygen therapy. Sessions were done at pressure 1.5 ATA (atmosphere absolute) with 100% oxygen concentration each lasting for 1–1.5 h either in multiplace chamber or monoplace chamber. MRI Perfusion of the brain was done before and after at least 20 HBOT sessions only for 6 cases.

Results

There was a statistically significant increase in the ratio of regional cerebral blood flow (RCBF) to white matter after HBOT in different brain regions when compared to their levels before HBOT.

Conclusion

Hyperbaric Oxygen Therapy is a treatment that has recently become quite popular in the autism spectrum disorder (ASD) community. Its benefits cross a wide range of autistic traits as: improved language, increased awareness, behavior and socialization by affecting the pathophysiological findings in autism.

Autism and Understanding It

For any parent with an autistic child, the news can be difficult to deal with at first. However, the aim here is to introduce you to Autism, so you have a better idea of what it is, and more importantly, how to best deal with it. Every autistic child's condition is different and every case requires specific recommendation.  

 

Autism Spectrum Disorders (ASDs) are characterized by the presence of impaired development in social interaction and communication and the presence of a restricted activity and interests [14]. The etiology of ASD is not currently known, which may in part explain why numerous widely divergent treatments for ASDs are in regular use. While genetic factors are clearly important, as indicated by high concordance ratesamong twins and siblings, they alone cannot account for an epidemic that developed in the relatively short period of 10– 20 years, however, environmental factors are very likely to account for the major portion of the increased prevalence of autism as many studies showed the presence of higher levels of heavy metals especially mercury in the hair of children with autism as compared to the age and sex matched healthy control [15].

  • Cerebral hypoperfusion in temporal regions and other brain areas in autistic children has been correlated with repetitive, self-stimulatory and stereotypical behaviors, and impairments in communication.

Hyperbaric oxygen therapy (HBOT) might be able to improve each of these problems in autistic children [4]. Specifically, HBOT has been used and can compensate for decreased blood flow by increasing the oxygen content of plasma and body tissues. HBOT has been reported to possess strong anti-inflammatory properties and has been shown to improve immune function [16]. HBOT can overcome the effects of cerebral hypoperfusion by providing more oxygen to the brain and by causing angiogenesis of new blood vessels over time by increasing Vascular Endothelial Growth Factor (VEGF) levels [17,18]. HBOT has been shown to decrease the infiltration of polymorphnuclear leucocytes (PMN’s) after an ischemic injury to the brain [19]. In addition, HBOT inhibits neutrophil attachment to blood vessel walls [20] and increases the distance that oxygen can travel in the interstitial space [21].

Treatment with HBOT has been shown to possess potent anti-inflammatory properties in both animal [22,23] and human studies [24,25]. HBOT has been reported to decrease the production of pro-inflammatory cytokines (including TNF-alpha, interferon-gamma, IL-1 and IL-6) in both animal [26,27] and human studies [28] as well as to increase counter-inflammatory IL-10 levels [29]. In one study, HBOT also decreased neopterin levels [30]. The effect of HBOT on reducing inflammation may be mediated through a pressure-related effect and not necessarily by the oxygen delivered.

The rationale for using HBOT for the treatment of ASDs is based on the recent findings of oxidative stress [31] and neuroinflammation [32] in ASDs and initial evidence that HBOT may alleviate oxidative stress in rats with pancreatitis [33] and decrease inflammatory responses in rats [34].

This study was conducted on 20 autistic children, 75% of autistic children were diagnosed before the age of 3 years, while the remaining 25% were diagnosed after the age of three years. Autistic group’s age ranged from 2 to 9 years with an average age 5.68 years. These findings are in agreement with Jonson, CP who found that a delay in child’s starting to speak around age two brings problems to parents’ attention, even though other, less noticeable signs may be present at an earlier age [35].

Other studies reported that parents are often aware of developmental problems in their child from age 18 months, but a diagnosis is often not made until 2 years after the initial expression of parental concern. In some cases diagnosis has not been confirmed until close to age 6 years, which is sometimes associated with delays attributable to access to services and regional variations in diagnosis [36].

 

In the current study 85% of autistic children were males, and 15% were females, with male/female ratio 5.6:1, and this goes with other studies, one of them involved 2685 patients with autism, the prevalence was more in males than females (ratio of 3.4–6.5) [37], while other investigators reported male:female ratio 2.8–5.5 [38].

Concerning ASD in the present study, 100% of the autistic group were typically autistic (AD). Ninety patients were on speech therapy, 55% were on behavioral therapy, 30% were on risperdal, 15% were on casein and gluten free diet, and 75% were on multivitamins. The key non-biomedical therapy employed by the majority of parents surveyed was speech therapy (75.3%), the next most frequently used therapies were applied behavioral analysis (ABA) and sensory integration which were used by 34.7% and 28.8% respectively.

Approximately 50–60% of children were on one of the commonly used diets, e.g., Gluten/Casein Free, Gluten/Casein/Soy free, sugar removed, chocolate removed, and Specific Carbohydrate Diet. In our study, significant improvement was observed in the ATEC scale in total score, subscales (sociability, sensory/cognitive awareness, and health/physical/behavior, communication) and CARS after completing at least twenty sessions of HBOT at 1.5 ATA and 100% oxygen.

The average improvement of ATEC total score in all children was 32.1%, and the average improvement of CARS score in all children was 15.1%.

In another study, in which six children completed 40, 1 h sessions of low pressure HBOT at 1.3 ATA and 28–30% oxygen, reported an average improvement of ATEC total score in all children as 22.1%, the average improvement of CARS score in all children as 12.1% [6]. As regard to CARS, in our study 100% of moderate cases of autism changed to the mild degree, 6% of severe cases also changed to the mild degree, 31% of severe cases changed to the moderate degree, so the lesser the degree of autism the more is the response. In our study ATEC scores also improved by 25.8% in the younger age group compared to 34% in the older age group, and CARS improved by 15.4% in the younger age group and 15% in the older age group. In contrary to our study, other researchers reported that ATEC scores improved by 31.6% in the younger age group compared to 8.8% in the other studies showed that hypoperfusion of the prefrontal and left temporal areas worsened and became ‘‘quite profound’’ in autistic children as the age of the autistic child increased. This diminished perfusion correlated with decreased language development.

The authors concluded that hypoperfusion ‘‘subsequently prevents development of true verbal fluency and development in the temporal and frontal areas associated with speech and communication’’ [47].

  • In conclusion, HBOT is a treatment that has recently become quite popular in the ASD community. Its benefits cross a wide range of autistic traits as: it improves language, increases awareness, behavior and socialization.

  • We recommend that the child should undergo a minimum of 40 sessions. Some children may require up to 80 sessions to see benefits.

Autism Facts – Chronic Neurological Inflammation Due To Inadequate Circulation And Excitotoxicity

  • Inflammation plays a significant role in a number of neurological and psychiatric conditions. Functional BOLD (Blood Oxygen Level Dependency) 3.5 Tesla MRI demonstrate regions of inadequate perfusion causing ischemic induced hypoxia (lack of tissue Oxygenation) resulting in chronic inflammation (elevated IL1,2,6 and TNF-a). Functional BOLD MRI are more advanced the normal 1.5 Tesla MRI which are often reported as being normal with autistic children.

  • Regions of inadequate perfusion and circulation also causes metabolic and biochemical disturbances and inflammation in the developing brain. Inflammation in the brain can affect kids both globally and locally too, and can be particularly impactful on the temporal lobes. The temporal lobes are found on the side of the head and the left side is where some of the language areas. When you have inflammation in those areas, blood flow can be decreased which hampers the ability for the blood to deliver Oxygen. You can see that can be very problematic.

  • Many children with brain injury often have delayed development, inadequate speech and very immature social skills simply because the brain disturbances become reinforced over time with 'disability being acquired'.

  • An excellent book on this topic of neuroplasticity is by Dr Norman Doidge 'The Brain That Changes Itself'. Dr Doidge's book is available at most book shops and parents of autistic children are encouraged to review.

  • Poor brain circulation leads to localized tissue hypoxia and other microcirculatory dysfunction.

  • Hyperbaric Oxygenation provides an enormous opportunity to assist both the child and adult with autistic challenges. Hyperbaric Oxygenation increases the nett delivery of Oxygenated blood into deprived regions of the brain. HBOT 'revascularizes' regions of inadequate blood flow. Stem Cells Mobilization and Hyperbaric Oxygenation

  • Neuro-HBOT recommended for children with brain injury is similar to traditional wound healing HBOT however treatment pressures are lower but the exposure time longer.

  • Increased Oxygen delivery into the central nervous systems structures enables the brains ability to better regulate biochemical reactions, mobilizing neural stem cells supporting autistic recovery. Hyperbaric Oxygenation kills chronic underlying opportunistic infections including bacteria and viral based DNA infections (Chlamydia, Mycoplasma, Herpes strains etc) that have been linked with many neurologic patients and also children with autistic disorders.

  • Many children with autism can have an issue with digestive inflammation and particularly inflammatory bowel disease; any type of inflammation whether it is in the gut, the blood stream, whether it is from a virus or a vaccine reaction or food sensitivities can negatively impact the brain. Hyperbaric Oxygenation impacts underlying gut issues and sensitivities. 

Mol Psychiatry. 2016 May 24. doi: 10.1038/mp.2016.77. [Epub ahead of print]

Autism with intellectual disability is associated with increased levels of maternal cytokines and chemokines during gestation.

Jones KL1,2, Croen LA3, Yoshida CK3, Heuer L1,2, Hansen R2,4, Zerbo O3, DeLorenze GN3, Kharrazi M5, Yolken R6, Ashwood P2,7, Van de Water J1,2.

Author information

Abstract

Immune abnormalities have been described in some individuals with autism spectrum disorders (ASDs) as well as their family members. However, few studies have directly investigated the role of prenatal cytokine and chemokine profiles on neurodevelopmental outcomes in humans. In the current study, we characterized mid-gestational serum profiles of 22 cytokines and chemokines in mothers of children with ASD (N=415), developmental delay (DD) without ASD (N=188), and general population (GP) controls (N=428) using a bead-based multiplex technology. The ASD group was further divided into those with intellectual disabilities (developmental/cognitive and adaptive composite score<70) (ASD+ID, N=184) and those without (composite score⩾70) (ASD-noID, N=201). Levels of cytokines and chemokines were compared between groups using multivariate logistic regression analyses, adjusting for maternal age, ethnicity, birth country and weight, as well as infant gender, birth year and birth month.

Mothers of children with ASD+ID had significantly elevated mid-gestational levels of numerous cytokines and chemokines, such as granulocyte macrophage colony-stimulating factor, interferon-γ, interleukin-1α (IL-1α) and IL-6, compared with mothers of children with either ASD-noID, those with DD, or GP controls. Conversely, mothers of children with either ASD-noID or with DD had significantly lower levels of the chemokines IL-8 and monocyte chemotactic protein-1 compared with mothers of GP controls. This observed immunologic distinction between mothers of children with ASD+ID from mothers of children with ASD-noID or DD suggests that the intellectual disability associated with ASD might be etiologically distinct from DD without ASD. These findings contribute to the ongoing efforts toward identification of early biological markers specific to subphenotypes of ASD. Molecular Psychiatry advance online publication, 24 May 2016; doi:10.1038/mp.2016.77.

BMC Pediatrics 2009, 9:21 doi:10.1186/1471-2431-9-21

Daniel A. Rossignol, Lanier W. Rossignol, Scott Smith, Cindy Schneider, Sally Logerquist, Anju Usman, Jim Neubrander, Eric M. Madren, Gregg Hintz, Barry Grushkin, Elizabeth A. Mumper

Abstract

Background
Several uncontrolled studies of hyperbaric treatment in children with autism have reported clinical improvements; however, this treatment has not been evaluated to date with a controlled study. We performed a multicenter, randomized, double-blind, controlled trial to assess the efficacy of hyperbaric treatment in children with autism.

Methods
62 children with autism recruited from 6 centers, ages 2-7 years (mean 4.92±1.21), were randomly assigned to 40 hourly treatments of either hyperbaric treatment at 1.3 atmosphere (atm) and 24% oxygen (“treatment group”, n=33) or slightly pressurized room air at 1.03 atm and 21% oxygen (“control group”, n=29). Outcome measures included Clinical Global Impression (CGI) scale, Aberrant Behavior Checklist (ABC), and Autism Treatment Evaluation Checklist (ATEC).

Results
After 40 sessions, mean physician CGI scores significantly improved in the treatment group compared to controls in overall functioning (p=0.0008), receptive language (p<0.0001), social interaction (p=0.0473), and eye contact (p=0.0102); 9/30 children (30%) in the treatment group were rated as “very much improved” or “much improved” compared to 2/26 (8%) of controls (p=0.0471); 24/30 (80%) in the treatment group improved compared to 10/26 (38%) of controls (p=0.0024). Mean parental CGI scores significantly improved in the treatment group compared to controls in overall functioning (p=0.0336), receptive language (p=0.0168), and eye contact (p=0.0322). On the ABC, significant improvements were observed in the treatment group in total score, irritability, stereotypy, hyperactivity, and speech (p

Conclusions
Children with autism who received hyperbaric treatment at 1.3 atm and 24% oxygen for 40 hourly sessions had significant improvements in overall functioning, receptive language, social interaction, eye contact, and sensory/cognitive awareness compared to children who received slightly pressurized room air.

Trial Registration: clinicaltrials.gov NCT00335790